Conformational Nonequilibrium Enzyme Kinetics: Generalized Michaelis–Menten Equation
نویسندگان
چکیده
منابع مشابه
Conformational Nonequilibrium Enzyme Kinetics: Generalized Michaelis-Menten Equation.
In a conformational nonequilibrium steady state (cNESS), enzyme turnover is modulated by the underlying conformational dynamics. On the basis of a discrete kinetic network model, we use an integrated probability flux balance method to derive the cNESS turnover rate for a conformation-modulated enzymatic reaction. The traditional Michaelis-Menten (MM) rate equation is extended to a generalized f...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry Letters
سال: 2017
ISSN: 1948-7185
DOI: 10.1021/acs.jpclett.7b01210